NQ 301 ( )
货号：
5724/50 基本售价：
7515.2 元 规格：
50 mg
产品信息
概述| 货号 | 5724/50 |
| 别名 | 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione |
性能| 供应商 | Tocris |
| 生物活性 | Selective CD45 inhibitor (IC50 = 200 nM). Exhibits >200-fold selectivity for CD45 over six related protein tyrosine phosphatases. Increases phosphorylation of Lck in Jurkat cells and reduces T cell receptor signaling in acitvated splenocytes in vitro. Blocks inflammation in a delayed-type hypersensitivity model in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 325.75 |
| 分子式 | C18H12ClNO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Perronet al (2014) Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo. Mol.Pharmacol. 85 553. PMID: 24473749. |
