| 货号 | 5398/50 |
| 别名 | N-(1,4-Dihydro-1,4-dioxo-2-naphthal |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of Aβ oligomer and fibril formation (IC50 = 50 nM for formation of fibrils from Aβ1-42). Reduces cytotoxicity of Aβ oligomers and increases cell viability in neuronal cells. Significantly extends lifespan of Drosophila expressing human Aβ1-42 . |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 360.36 |
| 分子式 | C21H16N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Zhanget al (2013) Atomic and dynamic insights into the beneficial effect of the 1,4-naphthoquinon-2-yl-L-tryptophan inhibitor on Alzheimer's Aβ1-42 dimer in terms of aggregation and toxicity. ACS Chem.Neurosci. 5 148. PMID: 24246047. Scherzer-Attaliet al (2010) Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor. PLoS ONE 5 e11101. PMID: 20559435. |