Glycerophospho-N-Eicosapentaenoyl Ethanolamine
货号：
90001842-10mg 基本售价：
7504.0 元 规格：
10 mg
产品信息
概述| 货号 | 90001842-10mg |
| 描述 | N-Acylated ethanolamines (NAEs) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (Item No. 90050) is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid (CB) receptors, central CB1 and peripheral CB2. The different types of NAEs are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1.1 Glycerophospho-N-eicosapentaenoyl ethanolamine is the metabolic precursor of eicosapentaenoyl ethanolamide (EPEA; Item No. 10964). EPEA is an NAE that inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.2 EPEA also has anti-inflammatory properties, suppressing the expression of IL-6 and MCP-1 in 3T3-L1 adipocytes in response to lipopolysaccharide.3 |
| 别名 | GP-NEPEA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Simon, G.M., and Cravatt, B.F. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. The Journal of Biological Chemisty 283, 9341-9349 (2008).
2.Lucanic, M.,Held, J.M.,Vantipalli, M.C., et al. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature 473(7346), 226-229 (2011).
3.Balvers, M.G.,Verhoeckx, K.C.,Plastina, P., et al. Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties. Biochimica et Biophysica Acta 1801(10), 1107-1114 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 499.6 |
| 分子式 | C25H42NO7P |
| 稳定性 | ≥ 2 years |
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