LY2886721
货号：
21599-25mg 基本售价：
7504.0 元 规格：
25 mg
产品信息
概述| 货号 | 21599-25mg |
| 描述 | LY2886721 selectively inhibits the β-site amyloid protein cleaving enzyme (BACE) (IC50 = 20 nM for recombinant hBACE1).1 BACE performs the first cleavage step in the Aβ cascade; thus, its inhibition by LY2886721 decreases production of all forms of the Aβ peptide.2 A Phase II clinical study for the use of LY2886721 in the treatment of Alzheimer’s disease was terminated early due to abnormal liver biochemistry values in several patients. The toxic effects did not appear to be due to BACE inhibition. |
| 别名 | β-Secretase; |
性能| 供应商 | Cayman |
| 应用文献 |
1.May, P.C.,Boggs, L.N.,Brier, R., et al. Preclinical characterization of LY2886721: A BACE1 inhibitor in clinical development for early Alzheimer’s disease. J. Alzheim. Assoc. 8(4), 95 (2003).
2.Vassar, R.,Kovacs, D.M.,Yan, R., et al. The beta-secretase enzyme BACE in health and Alzheimer’s disease: regulation, cell biology, function, and therapeutic potential. J. Neurosci. 29(41), 12787-12794 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.4 |
| 分子式 | C18H16F2N4O2S |
| CAS号 | 1262036-50-9 |
| 稳定性 | ≥ 2 years |
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