Glycerophospho-N-Oleoyl Ethanolamine
货号：
10011357-10mg 基本售价：
7504.0 元 规格：
10 mg
产品信息
概述| 货号 | 10011357-10mg |
| 描述 | N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (AEA) is an endogenous cannabinoid neurotransmitter that evokes cellular responses by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). The different types of NAE are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1 (GDE1).1 Glycerophospho-N-oleoyl ethanolamine is the precursor of oleoyl ethanolamide (OEA). OEA is an endogenous, potent agonist for PPARα, exhibiting an EC50 value of 120 nM in a transactivation assay.2 Systemic administration of OEA suppresses food intake and reduces weight gain in rats (10 mg/kg intraperitoneally) and PPARα wild-type mice, but not in PPARα knockout mice.2,3 Like AEA, OEA is metabolized by fatty acid amide hydrolase (FAAH). |
性能| 供应商 | Cayman |
| 应用文献 |
1.Simon, G.M. and Cravatt, B.F. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. The Journal of Biological Chemisty 283, 9341-9349 (2008).
2.Fu, J.,Gaetani, S.,Oveisi, F., et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 425, 90-93 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 479.6 |
| 分子式 | C23H46NO7P |
| CAS号 | 201738-24-1 |
| 稳定性 | ≥ 2 years |
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