Torcetrapib
货号：
15028-50mg 基本售价：
7476.0 元 规格：
50 mg
产品信息
概述| 货号 | 15028-50mg |
| 描述 | Cholesteryl ester transfer protein (CETP) catalyzes the exchange of cholesteryl esters from high-density lipoprotein (HDL) cholesterol to apolipoprotein B-containing lipoproteins, including very low-density lipoprotein (VLDL) and LDL.1 Torcetrapib is an inhibitor of CETP activity (IC50 = 50 nM) that raises HDL cholesterol and reduces LDL cholesterol levels by forming a nonproductive complex between CETP and HDL.2 Although torcetrapib produced consistent antiatherogenic effects in rabbits, clinical trials of torcetrapib were terminated early due to deleterious hypertensive effects.1,3 PDGFR, HGFR (c-Met), IL-2 receptor, and ErbB1- tyrosine kinase have subsequently been identified as direct off-targets of this compound.4 |
| 别名 | CP 529,414; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Barter, P.J.,Brewer, H.B., Jr.,Chapman, M.J., et al. Cholesteryl ester transfer protein: A novel target for raising HDL and inhibiting atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 23, 160-167 (2003).
2.Clark, R.W.,Ruggeri, R.B.,Cunningham, D., et al. Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of action. Journal of Lipid Research 47, 537-552 (2006).
3.Fan, S.,Geng, Q.,Pan, Z., et al. Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst.Biol. 6(152), (2012).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 600.5 |
| 分子式 | C26H25F9N2O4 |
| CAS号 | 262352-17-0 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
