Arachidonoyl-2-Fluoroethylamide
货号：
90054-100mg 基本售价：
7448.0 元 规格：
100 mg
产品信息
概述| 货号 | 90054-100mg |
| 描述 | Arachidonoyl-2-fluoroethylamide (2-fluoro AEA) is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution adds considerably increased binding affinity for the CB1 receptor (Kis = 26.7 and 908 nM for CB1 and CB2, respectively). It also contributes additional selectivity, in that binding to CB2 is decreased relative to AEA.1 However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. |
| 别名 | 2-fluoro AEA;2-fluoro Anandamide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, S.,Khanolkar, A.D.,Fan, P., et al. Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. Journal of Medicinal Chemistry 41, 5353-5361 (1998).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 349.5 |
| 分子式 | C22H36FNO |
| CAS号 | 166100-37-4 |
| 稳定性 | ≥ 1 year |
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