| 货号 | 12720-10mg |
| 描述 | 15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2 (Item No. 12010). The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle.1,2,3PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP14 and CRTH2/DP2.5,6 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2receptor.7 The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.7 |
| 别名 | 15(R)-15-methyl PGD2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hayaishi, O. Sleep-wake regulation by prostaglandins D2 and E2. The Journal of Biological Chemisty 263, 14593-14596 (1988). 2.Onoe, H.,Ueno, R.,Fujita, I., et al. Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. Proceedings of the National Academy of Sciences of the United States of America 85, 4082-4086 (1988). 3.Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35, 277-300 (1988). 4.Boie, Y.,Sawyer, N.,Slipetz, D.M., et al. Molecular cloning and characterization of the human prostanoid DP receptor. The Journal of Biological Chemisty 270, 18910-18916 (1995). 5.Monneret, G.,Gravel, S.,Diamond, M., et al. Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood 98(6), 1942-1948 (2001). 6.Hirai, H.,Tanaka, K.,Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. Journal of Experimental Medicine 193(2), 255-261 (2001). 7.Monneret, G.,Cossette, C.,Gravel, S., et al. 15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils. Journal of Pharmacology and Experimental Therapeutics 304(1), 349-355 (2003). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 366.5 |
| 分子式 | C21H34O5 |
| CAS号 | 210978-26-0 |
| 稳定性 | ≥ 1 year |
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