Δ12-Prostaglandin D2
货号：
12650-10mg 基本售价：
7448.0 元 规格：
10 mg
产品信息
概述| 货号 | 12650-10mg |
| 描述 | Prostaglandin D2(PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. Δ12-PGD2 is one of the initial chemical decomposition products of PGD2. Δ12-PGD2 is an intermediate in the pathway leading to Δ12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.1,2 The metabolism of Δ12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.3 |
| 别名 | Δ12-PGD2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fukushima, M. Prostaglandin J2 - antitumor and anti-viral activities and the mechanisms involved. Eicosanoids 3, 189-199 (1990).
2.Kato, T.,Fukushima, M.,Kurozumi, S., et al. Antitumor activity of Δ7-prostaglandin A1 and Δ12-prostaglandin J2 in vitro and in vivo. Cancer Research 46, 3538-3542 (1986).
3.Atsmon, J.,Sweetman, B.J.,Baertschi, S.W., et al. Formation of thiol conjugates of 9-deoxy-Δ9,Δ12(E)-prostaglandin D2 and Δ12(E)-prostaglandin D2. Biochemistry 29, 3760-3765 (1990).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 352.5 |
| 分子式 | C20H32O5 |
| CAS号 | 64072-89-5 |
| 稳定性 | ≥ 1 year |
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