N-Palmitoyl Dopamine
货号：
10007697-100mg 基本售价：
7448.0 元 规格：
100 mg
产品信息
概述| 货号 | 10007697-100mg |
| 描述 | Several different fatty acyl dopamine analogs, such as N-arachidonoyl dopamine (NADA), N-oleoyl dopamine (ODA) and N-palmitoyl dopamine (PALDA), have been isolated and characterized from bovine brain.1,2 Structurally, PALDA is the amide of palmitic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. Unlike NADA and ODA, PALDA is nearly inactive as a vanilloid receptor 1 (VR1) ligand and fails to elicit hyperalgesic or nocifensive responses in vivo.2 However, PALDA exhibits an “entourage” effect at concentrations of 0.1-10 µM by potentiating the VR1-mediated effects of NADA and anandamide.3 |
| 别名 | PALDA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, S.M.,Bisogno, T.,Petros, T.J., et al. Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. The Journal of Biological Chemisty 276(46), 42639-42644 (2001).
2.Chu, C.J.,Huang, S.M.,De Petrocellis, L., et al. N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. The Journal of Biological Chemisty 278(16), 13633-13639 (2003).
3.De Petrocellis, L.,Chu, C.J.,Moriello, A.S., et al. Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. British Journal of Pharmacology 143, 251-256 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 391.6 |
| 分子式 | C24H41NO3 |
| CAS号 | 136181-87-8 |
| 稳定性 | ≥ 1 year |
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