CAY10625
货号：
13836-10mg 基本售价：
7392.0 元 规格：
10 mg
产品信息
概述| 货号 | 13836-10mg |
| 描述 | Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/DIABLO, caspase-3, and caspase-7.1,2 Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. CAY10625 is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO, exhibiting an IC50 value of 2.2 µM.3 It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 µM. CAY10625 is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ryan, B.M.,ODonovan, N. and Duffy, M.J. Survivin: A new target for anti-cancer therapy. Cancer Treatment Reviews 35, 553-562 (2009).
2.Shin, S.,Sung, B.J.,Cho, Y.S., et al. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7. Biochemistry 40, 1117-1123 (2001).
3.Oikawa, T.,Unno, Y.,Matsuno, K., et al. Identification of a small-molecule inhibitor of the interaction between Survivin and Smac/DIABLO. Biochemical and Biophysical Research Communications 393, 253-258 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 446.5 |
| 分子式 | C25H26N4O4 |
| CAS号 | 137346-42-0 |
| 稳定性 | ≥ 2 years |
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