SB 225002
货号：
13336-50mg 基本售价：
7392.0 元 规格：
50 mg
产品信息
概述| 货号 | 13336-50mg |
| 描述 | CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC50 value of 22 nM.1 SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro(IC50 = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo(IC50 = 30 nM).1 Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.White, J.R.,Lee, J.M.,Young, P.R., et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. The Journal of Biological Chemisty 273(17), 10095-10098 (1998).
2.Bento, A.F.,Leite, D.F.P.,Claudino, R.F., et al. The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice. Journal of Leukocyte Biology 84, 1213-1221 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 352.1 |
| 分子式 | C13H10BrN3O4 |
| CAS号 | 182498-32-4 |
| 稳定性 | ≥ 2 years |
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