FK-866
货号：
13287-50mg 基本售价：
7392.0 元 规格：
50 mg
产品信息
概述| 货号 | 13287-50mg |
| 描述 | Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate step in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+depletion.1 In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM).1 In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that may be linked to decreased activity of the NAD+-dependent enzyme SIRT1.2 Also, FK-866 induces autophagy in SH-SY5Y neuroblastoma cells, as indicated by the formation of LC3-positive vesicles.3 |
| 别名 | K 22.175; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hasmann, M. and Schemainda, I. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Research 63, 7436-7442 (2003).
2.van der Veer, E.,Ho, C.,ONeil, C., et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. The Journal of Biological Chemisty 282(15), 10841-10845 (2007).
3.Billington, R.A.,Genazzani, A.A.,Travelli, C., et al. NAD depletion by FK866 induces autophagy. Autophagy 4(3), 385-387 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 391.5 |
| 分子式 | C24H29N3O2 |
| CAS号 | 658084-64-1 |
| 稳定性 | ≥ 2 years |
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