CB-5083
货号：
19311-25mg 基本售价：
7350.0 元 规格：
25 mg
产品信息
概述| 货号 | 19311-25mg |
| 描述 | CB-5083 is an orally bioavailable inhibitor of p97 (IC50 = 11 nM), a transitional endoplasmic reticulum ATPase also known as valosin-containing protein (VCP).1,2 It disrupts cellular protein homeostasis and demonstrates anti-tumor activity in hematological and solid tumor models. CB-5083 causes accumulation of poly-ubiquitinated proteins, retention of endoplasmic reticulum-associated degradation (ERAD) substrates, and activation of the apoptotic arm of the unfolded protein response.1,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Anderson, D.J.,Le Moigne, R.,Dkjakovic, S., et al. Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis. Cancer Cell. 28(5), 653-665 (2015).
2.Zhou, H.-J.,Wang, J.,Yao, B., et al. Discovery of a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase (CB-5083). J. Med. Chem. 58(24), 9480-9497 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 413.5 |
| 分子式 | C24H23N5O2 |
| CAS号 | 1542705-92-9 |
| 稳定性 | ≥ 2 years |
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