NF-κB Control
货号：
17475-5mg 基本售价：
7350.0 元 规格：
5 mg
产品信息
概述| 货号 | 17475-5mg |
| 描述 | NF-κB inhibitor (Item No. 17493) is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1 It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1 NF-κB control is a peptide that is identical in sequence to NF-κB inhibitor, except two essential, basic residues of the p105 NLS are substituted with non-basic amino acids.1 It is ineffective at blocking the activation of NF-κB signaling and is used as a negative control peptide.1,2,3 |
| 别名 | SN50M; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lin, Y.Z.,Tao, S.,Veach, R.A., et al. Inhibition of nuclear translocation of transcription factor NF- k B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. The Journal of Biological Chemisty 270(24), 14255-14258 (1995).
2.Pahan, K.,Sheikh, F.G.,Liu, X., et al. Induction of nitric-oxide synthase and activation of NF-κB by interleukin-12 p40 in microglial cells. The Journal of Biological Chemisty 276(11), 7899-7905 (2001).
3.Kang, Y.M.,Gao, F.,Li, H.H., et al. NF-κB in the paraventricular nucleus modulates neurotransmitters and contributes to sympathoexcitation in heart failure. Basic Research in Cardiology 106(6), 1087-1097 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 2668.3 |
| 分子式 | C123H215N33O30S |
| CAS号 | 201608-17-5 |
| 稳定性 | ≥ 2 years |
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