UNC2170 (maleate)
货号：
17374-25mg 基本售价：
7350.0 元 规格：
25 mg
产品信息
概述| 货号 | 17374-25mg |
| 描述 | p53-Binding protein 1 (53BP1) binds to dimethylated lysine 20 on histone 4 (H4K20me2) via tandem tudor domains on a 53BP1 homodimer.1 This interaction is an important part of the DNA damage response.1 UNC2170 is a micromolar ligand of 53BP1 that binds to a pocket formed by the tandem tudor domains.2 It displays at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins.2 UNC2170 functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Botuyan, M.V.,Lee, J.,Ward, I.M., et al. Structural basis for the methylation state-specific recognition for histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127, 1361-1373 (2006).
2.Perfetti, M.T.,Baughman, B.M.,Dickson, B.M., et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chemical Biology 10(4), 1072-1081 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 429.3 |
| 分子式 | C14H21BrN2O • C4H4O4 |
| 稳定性 | ≥ 2 years |
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