AZD 2461
货号：
16876-25mg 基本售价：
7350.0 元 规格：
25 mg
产品信息
概述| 货号 | 16876-25mg |
| 描述 | The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. AZD 2461 is a PARP inhibitor (IC50 = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter.1 It was developed to overcome the resistance encountered with olaparib (Item No. 10621) that is presumed to be mediated in part by P-glycoprotein-mediated drug efflux.1 When tested on the olaparib-resistant KB1P tumor T6-28, which has an 80-fold increased Mdr1b expression, AZD 2461 did not affect P-glycoprotein.1 Furthermore, it can induce a loss of p53 binding protein 1 expression in mice with KB1P tumors at 100 mg/kg.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jaspers, J.E.,Kersbergen, A.,Boon, U., et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 3(1), 68-81 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 395.4 |
| 分子式 | C22H22FN3O3 |
| CAS号 | 1174043-16-3 |
| 稳定性 | ≥ 2 years |
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