GNF-2
货号：
16253-50mg 基本售价：
7350.0 元 规格：
50 mg
产品信息
概述| 货号 | 16253-50mg |
| 描述 | Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia. GNF-2 is a Bcr-Abl inhibitor that binds to the myristoyl binding pocket, an allosteric site distant from the active site, stabilizing the inactive form of the kinase.1 Thus, it can selectively inhibit Bcr-Abl phosphorylation (IC50 = 267 nM) without affecting native c-Abl or a panel of 63 additional kinases.1 It demonstrates exclusive antiproliferative activity toward Bcr-Abl-transformed cells (IC50 = 138 nM), inducing apoptosis in these cells without cytotoxic consequences in nontransformed cells.1 |
| 别名 | Bcr-Abl Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Adrián, F.J.,Ding, Q.,Sim, T., et al. Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nature Chemical Biology 2(2), 95-102 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 374.3 |
| 分子式 | C18H13F3N4O2 |
| CAS号 | 778270-11-4 |
| 稳定性 | ≥ 2 years |
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