| 货号 | 15933-25g |
| 描述 | Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions.1,2 It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM).3 Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone.4 It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously.4 In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.5 |
| 别名 | Disodium Prednisolone 21-Phosphate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brownie, A.C. The metabolism of adrenal cortical steroids. The Adrenal Gland 2, 209-225 (1992). 2.Yang, B.V.,Weinstein, D.S.,Doweyko, L.M., et al. Dimethyl-diphenyl-propanamide derivatives as nonsteroidal dissociated glucocorticoid receptor agonists. Journal of Medicinal Chemistry 53(23), 8241-8251 (2010). 3.Kym, P.R.,Kort, M.E.,Coghlan, M.J., et al. Nonsteroidal selective glucocorticoid modulators: The effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. Journal of Medicinal Chemistry 46(6), 1016-1030 (2003). 4.Frey, B.M.,Seeberger, M. and Frey, F.J. Pharmacokinetics of 3 prednisolone prodrugs. Evidence of therapeutic inequivalence in renal transplant patients with rejection. Transplantation 39(3), 270-274 (1985). 5.Bailey, E.,Murphy, D. and West, H.F. Oral prednisolone phosphate therapy. Archives of Disease in Childhood 38, 71-74 (1963). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 484.4 |
| 分子式 | C21H27O8P • 2Na |
| CAS号 | 125-02-0 |
| 稳定性 | ≥ 2 years |
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