| 货号 | 13597-100mg |
| 描述 | The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival.1 Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC50 = 10 nM).2 It does not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks.2 Ku-0063794 inhibits cell growth by inducing G1-cell cycle arrest and autophagy, but not apoptosis, and inhibits tumor growth in a xenograft model of renal cell carcinoma (8 mg/kg for 46 days).2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Carracedo, A., and Pandolfi, P.P. The PTEN-PI3K pathway: Of feedbacks and cross-talks. Oncogene 27, 5527-5541 (2008). 2.García-Martínez, J.M.,Moran, J.,Clarke, R.G., et al. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochemistry Journal 421, 29-42 (2009). 3.Fei, S.J.,Zhang, X.C.,Dong, S., et al. Targeting mTOR to overcome epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer cells. PLoS One 8(7), 69104 (2013). 4.Zhang, H.,Berel, D.,Wang, Y., et al. A comparison of Ku0063794, a dual mTORC1 and mTORC2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models. PLoS One 8(1), 54918 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 465.5 |
| 分子式 | C25H31N5O4 |
| CAS号 | 938440-64-3 |
| 稳定性 | ≥ 2 years |
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