| 货号 | 5299/50 |
| 别名 | 2-(Phenylthio)-N-[[tetrahydro-4-(4- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective P2X7 antagonist (pIC50 values are 8.3, 7.5 and 7.2 for human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces BzATP-induced IL-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine-induced hyperactivity in rats. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 488.64 |
| 分子式 | C28H32N4O2 |
| 可溶性/溶解性 | Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO |
| 参考文献 | Bhattacharyaet al (2013) Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ-47965567. Br.J.Pharmacol. 170 624. PMID: 23889535. Letavicet al (2013) Synthesis and pharmacological characterization of two novel, brain penetrating P2X7 antagonists. ACS Med.Chem.Lett. 12 419. PMID: 24900687. |