Reveromycin A
货号：
17458-1mg 基本售价：
7322.0 元 规格：
1 mg
产品信息
概述| 货号 | 17458-1mg |
| 描述 | Reveromycin A is the major component of a complex of spiroketal antibiotics isolated from Streptomyces sp. It inhibits the mitogenic activity of epidermal growth factor in Balb/MK cells (IC50 = 0.7 µg/ml), displays antiproliferative activity against human KB and K562 tumor cell lines (IC50s = 1.9 and 1.6 µg/ml, respectively), and demonstrates antifungal activity against C. albicans (MIC = 2 µg/ml at pH 3).1 Reveromycin A also has been shown to inhibit bone resorption by inducing apoptosis in osteoclasts with an IC50 value of 0.7 µM.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Takahashi, H.,Osada, H.,Koshino, H., et al. Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. J.Antibiot.(Tokyo) 45(9), 1414-1419 (1992).
2.Woo, J.T.,Kawatani, M.,Kato, M., et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proceedings of the National Academy of Sciences of the United States of America 103(12), 4729-4734 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 660.8 |
| 分子式 | C36H52O11 |
| CAS号 | 134615-37-5 |
| 稳定性 | ≥ 2 years |
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