Chetomin
货号：
14437-5mg 基本售价：
7320.0 元 规格：
5 mg
产品信息
概述| 货号 | 14437-5mg |
| 描述 | Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties.1 It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.2 Chetomin effectively attenuates the HIF pathway both in cells and in vivo, in mice.2 It inhibits HIF-dependant signaling, cell growth, and tumor growth in cancer cells and xenografts.2,3 |
| 别名 | NSC 289491; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mazumder, P.M. and Sasmal, D. Mycotoxins - limits and regulations. Anc.Sci.Life 20(3), 1-19 (2001).
2.Kung, A.L.,Zabludoff, S.D.,France, D.S., et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 6, 33-43 (2004).
3.Kessler, J.,Hahnel, A.,Wichmann, H., et al. HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: Effects on hypoxic radioresistance and monitoring via CA9 expression. BMC Cancer 10(605), (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 710.9 |
| 分子式 | C31H30N6O6S4 |
| CAS号 | 1403-36-7 |
| 稳定性 | ≥ 1 year |
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