20-HETE-d6
货号：
390030-100ug 基本售价：
7308.0 元 规格：
100 ug
产品信息
概述| 货号 | 390030-100ug |
| 描述 | 20-HETE-d6 contains six deuterium atoms at the 16, 16, 17, 17, 18 and 18 positions. It is intended for use as an internal standard for the quantification of 20-HETE by GC- or LC-mass spectrometry. 20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the renal and cerebral vasculature.1 In rat cerebral microvessels, 20-HETE is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction.2 20-HETE is excreted mainly as the glucuronide conjugate. The concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide.3 |
| 别名 | 20-hydroxy Arachidonic Acid-d6; |
性能| 供应商 | Cayman |
| 应用文献 |
1.McGiff, J.C. and Quilley, J. 20-HETE and the kidney: Resolution of old problems and new beginnings. American Journal of Physiology 277, R607-R623 (1999).
2.Gebremedhin, D.,Lange, A.R.,Lowry, T.F., et al. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circulation Research 87, 60-65 (2000).
3.Prakash, C.,Zhang, J.Y.,Falck, J.R., et al. 20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine. Biochemical and Biophysical Research Communications 185, 728-733 (1992).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d6) |
| 计算分子量 | 326.5 |
| 分子式 | C20H26D6O3 |
| 稳定性 | ≥ 6 months |
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