5(S)-HETE-d8
货号：
334230-100ug 基本售价：
7308.0 元 规格：
100 ug
产品信息
概述| 货号 | 334230-100ug |
| 描述 | 5(S)-HETE-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of 5(S)-HETE by GC- or LC-mass spectrometry (MS). 5(S)-HETE is produced by the action of 5-lipoxygenase on arachidonic acid to give 5(S)-HpETE, followed by reduction of the hydroperoxide. 5(S)-HETE has proliferative and chemotactic effects on granulocytes.1 When further metabolized to the 5-oxoETE, it is a more potent eosinophil chemoattractant than leukotriene B4.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schwenk, U., and Schröder, J.M. 5-oxo-Eicosanoids are potent eosinophil chemotactic factors. The Journal of Biological Chemisty 270, 15029-15036 (1994).
2.Powell, W.S.,Gravelle, F., and Gravel, S. Metabolism of 5(S)-hydroxy-6,8,11,14-eicosatetraenoic acid and other 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human polymorphonuclear leukocytes. The Journal of Biological Chemisty 267, 19233-19241 (1992).
3.Dodge, W., and Thomas, M. The effect of 5-hydroxyeicosatetraenoic acid on the proliferation of granulocyte progenitors and embryonic fibroblasts of the chick. Biochemical and Biophysical Research Communications 131, 731-735 (1985).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d8) |
| 计算分子量 | 328.5 |
| 分子式 | C20H24D8O3 |
| CAS号 | 330796-62-8 |
| 稳定性 | ≥ 1 year |
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