| 货号 | 9001510-10mg |
| 描述 | Erlotinib (Item No. 10483) is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC50 = 2.5 µM).1,2 It binds to the EGF-activated receptor, with the phenyl group at one end sequestered in a hydrophobic pocket of the kinase domain and the ether linkages at the opposite end projecting into solvent.3,4 4-methyl Erlotinib is an analog of erlotinib characterized by the addition of a methyl group at the four position of the phenyl group. The biochemical and physiological properties of this compound are not known. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Pollack, V.A.,Savage, D.M.,Baker, D.A., et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice. Journal of Pharmacology and Experimental Therapeutics 291, 739-748 (1999). 2.Greulich, H.,Chen, T.H.,Feng, W., et al. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2(11), (2005). 3.Stamos, J.,Sliwkowski, M.X., and Eigenbrot, C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. The Journal of Biological Chemisty 277(48), 46265-46272 (2002). 4.Park, J.H., and Lemmon, M.A. Occupy EGFR. Cancer Discov. 2(5), 398-400 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 407.5 |
| 分子式 | C23H25N3O4 |
| CAS号 | 1346601-52-2 |
| 稳定性 | ≥ 2 years |
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