| 货号 | 9001232-10mg |
| 描述 | N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Docosahexaenoyl ethanolamide (DHEA) has potential signaling roles in cancer, inflammation, and neurological development and functioning.1,2,3,4 At least some of DHEA’s effects are mediated through cannabinoid (CB) receptors, while some NAEs also act as vanilloid receptor agonists and voltage-gated K+ channel blockers.5,1,4 (S)-(−)-Docosahexaenyl-1’-hydroxy-2’-propylamide is a homolog of DHEA, characterized by the addition of an (S)-α-methyl group at the methylene carbon adjacent to the amide nitrogen. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce S-1 methanandamide (Item No. 90072) results in a diminished affinity for the CB receptor but greatly improved metabolic stability to aminopeptidase hydrolysis.6 The physiological actions of this compound have not been evaluated. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brown, I.,Cascio, M.G.,Wahle, K.W.J., et al. Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis 31(9), 1584-1591 (2010). 2.Kim, H.Y.,Moon, H.S.,Cao, D., et al. N-docosahexaenoylethanolamide promotes development of hippocampal neurons. Biochemistry Journal 435, 327-336 (2011). 3.Balvers, M.G.,Verhoeckx, K.C.,Plastina, P., et al. Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties. Biochimica et Biophysica Acta 1801(10), 1107-1114 (2010). 4.Poling, J.S.,Rogawski, M.A.,Salem, N., Jr., et al. Anadamide, an endogenous cannabinoid, inhibits shaker-related voltage-gated K+ channels. Neuropharmacology 35(7), 983-991 (1996). 5.Calignano, A.,LaRana, G., and Piomelli, D. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. European Journal of Pharmacology 419(2-3), 191-198 (2001). 6.Abadji, V.,Lin, S.,Taha, G., et al. (R)-Methanandamide: A chiral novel anandamide possessing higher potency and metabolic stability. Journal of Medicinal Chemistry 37, 1889-1893 (1994). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 385.6 |
| 分子式 | C25H39NO2 |
| 稳定性 | ≥ 1 year |
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