| 货号 | 19025-10mg |
| 描述 | SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM.1 It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 µM.2 It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM.3 SQ 29,548 also inhibits the contraction of rat vascular smooth muscle induced by 8-isoPGF2α.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Abramovitz, M.,Adam, M.,Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000). 2.Ogletree, M.L.,Harris, D.N.,Greenberg, R., et al. Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist. Journal of Pharmacology and Experimental Therapeutics 234, 435-441 (1985). 3.Ogletree, M.L., and Allen, G.T. Interspecies differences in thromboxane receptors: Studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. Journal of Pharmacology and Experimental Therapeutics 260, 789-794 (1992). 4.Fukunaga, M.,Makita, N.,Roberts, L.J., II, et al. Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. American Journal of Physiology 264, C1619-C1624 (1993). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 387.5 |
| 分子式 | C21H29N3O4 |
| CAS号 | 98672-91-4 |
| 稳定性 | ≥ 1 year |
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