| 货号 | 18874-5mg |
| 描述 | (R)-Omeprazole is the inactive isomer of omeprazole (Item No. 14880), a gastric proton-pump inhibitor.1,2 A stereoselective hydroxylation of (R)-omeprazole is mediated primarily by cytochrome P450 (CYP) 2C19, whereas CYP3A4 favors sulfoxidation of the active (S)-enantiomer (esomeprazole magnesium, Item No. 17326).3 (R)-Omeprazole has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 8.1 µM).4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shi, S., and Klotz, U. Proton pump inhibitors: An update of their clinical use and pharmacokinetics. Eur. J. Clin. Pharmacol. 64, 935-951 (2008). 2.Lind, T.,Rydberg, L.,Kylebäck, A., et al. Esomeprazole provides improved acid control vs. omeprazole in patients with symptoms of gastro-oesophageal reflux disease. Alimentary Pharmacology and Therapeutics 14, 861-867 (2000). 3.Äbelö, A.,Andersson, T.B.,Antonsson, M., et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metabolism and Disposition 28(8), 966-972 (2000). 4.Ogilvie, B.W.,Yerino, P.,Kazmi, F., et al. The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: Implications for coadministration with clopidogrel. Drug Metabolism and Disposition 39(11), 2020-2033 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.4 |
| 分子式 | C17H19N3O3S • Na |
| CAS号 | 161796-77-6 |
| 稳定性 | ≥ 2 years |
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