TCS 5861528
货号：
18380-50mg 基本售价：
7280.0 元 规格：
50 mg
产品信息
概述| 货号 | 18380-50mg |
| 描述 | The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse, potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation. TCS 5861528 is a selective TRPA1 blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal (Item No. 32100) with IC50 values of 14.3 and 18.7 μM, respectively.1,2 At 30 mg/kg twice daily in rats, TCS 5861528 has been used to attenuate pain-related behavior in models of diabetic hypersensitivity and postoperative pain.1,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wei, H.,Hämäläinen, M.M.,Saarnilehto, M., et al. Attenuation of the mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111, 147-154 (2009).
2.Fanger, C.M.,del Camino, D., and Moran, M.M. TRPA1 as an analgesic target. Open Drug Discov.J. 2, 64-70 (2010).
3.Wei, H.,Karimaa, M.,Korjamo, T., et al. Transient receptor potential ankyrin 1 ion channel contributes to guarding pain and mechanical hypersensitivity in a rat model of postoperative pain. Anesthesiology 117(1), 137-148 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 369.4 |
| 分子式 | C19H23N5O3 |
| CAS号 | 332117-28-9 |
| 稳定性 | ≥ 2 years |
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