Eggmanone
货号：
17751-10mg 基本售价：
7280.0 元 规格：
10 mg
产品信息
概述| 货号 | 17751-10mg |
| 描述 | Type 4 cyclic nucleotide phosphodiesterase (PDE4) selectively inactivates the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. PDE4 has been reported to play a key regulatory role in Hedgehog signaling downstream of smoothened and, thus, represents a potential therapeutic target for Hedgehog-dependent cancers.1 Eggmanone is a selective inhibitor of PDE4 (IC50 = 72 nM) that antagonizes the Hedgehog signaling pathway.1 It demonstrates 40- to 50-fold lower potency at PDE3, PDE10, and PDE11 (IC50s = 3, 3.05, and 4.08 µM, respectively).1 Inhibition of PDE4 activity via eggmanone was shown to activate localized protein kinase A signaling, which, in turn, regulates Gli processing and translocation.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Williams, C.H.,Hempel, J.E.,Hao, J., et al. An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11(1), 43-50 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 416.6 |
| 分子式 | C20H20N2O2S3 |
| CAS号 | 505068-32-6 |
| 稳定性 | ≥ 2 years |
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