| 货号 | 17598-50mg |
| 描述 | 3,3,5’-Triiodo-L-thyronine, also known as reverse T3 (rT3), is a thyroid hormone generated by deiodination of the prohormone thyroxine. It is about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ than 3,3,5-triiodo-L-thyronine (Item No. 16028) and commonly described as inactive.1,2 However, high serum levels of rT3 are found in neonates and in certain conditions.3,4,5,6 It reportedly activates TRΔα1, a native form of TRα that lacks a nuclear localization signal and functions in the cytoplasm.7 Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons.7 |
| 别名 | Reverse T3;rT3;3,3’,5’-T3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Collingwood, T.N.,Sydenham, M.,Page, M.J., et al. Functional properties of human thyroid hormone receptor β1 overexpressed using baculovirus. FEBS Letters 291(2), 315-318 (1991). 2.Koury, E.J.,Pawlyk, A.C.,Berrodin, T.J., et al. Characterization of ligands for thyroid receptor subtypes and their interactions with co-regulators. Steroids 74(2), 270-276 (2009). 3.Tien, E.S.,Matsui, K.,Moore, R., et al. The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liver. Journal of Pharmacology and Experimental Therapeutics 320(1), 307-313 (2007). 4.Ohguchi, H.,Tanaka, T.,Uchida, A., et al. Hepatocyte nuclear factor 4α contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Krüppel-like transcription factor 9. Molecular and Cellular Biology 28(12), 3917-3931 (2008). 5.Economidou, F.,Douka, E.,Tzanela, M., et al. Thyroid function during critical illness. Hormones 10(2), 117-124 (2011). 6.Novitzky, D., and Cooper, D.K.C. Thyroid hormone and the stunned myocardium. Journal of Endocrinology 223(1), R1-R8 (2014). 7.Senese, R.,Cioffi, F.,de Lange, P., et al. Thyroid: Biological actions of “nonclassical” thyroid hormones. Journal of Endocrinology 221(2), R1-R12 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 651 |
| 分子式 | C15H12I3NO4 |
| CAS号 | 5817-39-0 |
| 稳定性 | ≥ 2 years |
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