Clozapine-d4
货号：
17513-500ug 基本售价：
7280.0 元 规格：
500 ug
产品信息
概述| 货号 | 17513-500ug |
| 描述 | Clozapine-d4 contains four deuterium atoms on the piperazinyl ring. It is intended for use as an internal standard for the quantification of clozapine (Item No. 12059) by GC- or LC-mass spectrometry. Clozapine is a partial agonist at the 5-HT1A receptor (pKi = 7) and interferes to a lesser extent with the binding of dopamine at D1, D2, D3, and D5 receptors, yet has a high affinity for the D4receptor.1 It is also a strong antagonist at different subtypes of adrenergic, cholinergic, and histaminergic receptors. Clozapine induces the release of glutamate and D-serine, an agonist at the glycine site of the NMDA receptor, from astrocytes, and reduces the expression of astrocytic glutamate transporters.2 |
| 别名 | Azaleptin-d4;Fazaclo-d4;HF 1854-d4;Iprox-d4;Sizopin-d4; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Millan, M.J. Improving the treatment of Schizophrenia: focus on serotonin (5-HT)1A receptors. Journal of Pharmacology and Experimental Therapeutics 295(3), 853-861 (2000).
2.Tanahashi, S.,Yamamura, S.,Nakagawa, M., et al. Clozapine, but not haloperidol, enhances glial D-serin and L-glutamate release in rat frontal cortex and primary cultured astrocytes. British Journal of Pharmacology 165, 1543-1555 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 330.9 |
| 分子式 | C18H15D4ClN4 |
| CAS号 | 204395-52-8 |
| 稳定性 | ≥ 2 years |
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