Ximelagatran
货号：
16862-5mg 基本售价：
7280.0 元 规格：
5 mg
产品信息
概述| 货号 | 16862-5mg |
| 描述 | Ximelagatran is an ester prodrug of melagatran, a potent, direct, and reversible thrombin inhibitor (Ki = 1.2 nM).1,2 While melagatran has poor oral bioavailability, ximelagatran displays good bioavailability resulting, in part, from rapid absorption at the gastrointestinal tract, as well as rapid onset of action.2 Ximelagatran is converted to melagatran by reduction and hydrolysis at the liver and other tissues.1,2 It is used as an anticoagulant in a variety of situations, including thromboembolic disorders, stroke prevention in atrial fibrillation, and therapy in vein thrombosis.2,3 |
| 别名 | Exanta;H 376/95; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Clement, B., and Lopian, K. Characterization of in vitro biotransformation of new, orally active, direct thrombin inhibitor ximelagatran, an amidoxime and ester prodrug. Drug Metabolism and Disposition 31(5), 645-651 (2003).
2.Ho, S.J., and Brighton, T.A. Ximelagatran: Direct thrombin inhibitor. Vascular Health and Risk Management 2(1), 49-58 (2006).
3.Ufer, M. Comparative pharmacokinetics of vitamin K antagonists warfarin, phenprocoumon and acenocoumarol. Clinical Pharmacokinetics 44(12), 1227-1246 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 473.6 |
| 分子式 | C24H35N5O5 |
| CAS号 | 192939-46-1 |
| 稳定性 | ≥ 2 years |
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