| 货号 | 16376-500mg |
| 描述 | S-(5-Adenosyl)-L-methionine (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases.1,2,3 SAM (tosylate) (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use.4 SAMe reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity.5,4,6,7,8 |
| 别名 | SAMe; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chiang, P.K. Biological effects of inhibitors of S-adenosylhomocysteine hydrolase. Pharmacology & Therapeutics 77(2), 115-134 (1998). 2.Loenen, W.A.M. S-Adenosylmethionine: Jack of all trades and master of everything? Biochemical Society Transactions 34(2), 330-333 (2006). 3.Chiang, P.K.,Gordon, R.K.,Tal, J., et al. S-adenosylmethionine and methylation. The FASEB Journal 10, 471-480 (1996). 4.Najm, W.I.,Reinsch, S.,Hoehler, F., et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskeletal Disorders 5, 1-15 (2004). 5.De Berardis, D.,Marini, S.,Serroni, N., et al. S-Adenosyl-L-Methionine augmentation in patients with stage II treatment-resistant major depressive disorder: An open label, fixed dose, single-blind study. ScientificWorldJournal 2013, 1-6 (2013). 6.Parcell, S. Sulfur in human nutrition and applications in medicine. Altern.Med.Rev. 7(1), 22-44 (2002). 7.Liu, G.Y.,Wang, W.,Jia, W.D., et al. Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection. World J.Surg.Oncol. 12, 1-8 (2014). 8.Anstee, Q.M. and Day, C.P. S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility. Journal of Hepatology 57(5), 1097-1109 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 570.6 |
| 分子式 | C15H23N6O5S • C7H7O3S |
| CAS号 | 52248-03-0 |
| 稳定性 | ≥ 2 years |
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