RKI-1447
货号：
16278-50mg 基本售价：
7280.0 元 规格：
50 mg
产品信息
概述| 货号 | 16278-50mg |
| 描述 | RKI-1447 is an inhibitor of the Rho-associated kinases ROCK-I and II (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase.1 In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase.1 Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Patel, R.A.,Forinash, K.D.,Pireddu, R., et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and anti-tumor activities in breast cancer. Cancer Research 72(19), 5025-5034 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 326.4 |
| 分子式 | C16H14N4O2S |
| CAS号 | 1342278-01-6 |
| 稳定性 | ≥ 2 years |
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