| 货号 | 15301-1g |
| 描述 | trans-Vaccenic acid is a naturally occurring trans-fatty acid found in the fat of ruminants as well as in the meat and dairy products produced from these animals.1 In mammals, trans-vaccenic acid is converted to 9(Z),11(E)-conjugated linoleic acid (Item No. 90140), which has been shown to have beneficial antioxidant and antitumor activities that have been attributed to competitive inhibition of Δ6-desaturase and/or PPARγ activation.1,2,3 Additionally, a trans-vaccenic acid-rich diet has been reported to reduce serum cholesterol and triglyceride levels when fed to LDL receptor deficient mice representing an animal model of atherosclerosis.4,5 |
| 别名 | trans-11-Octadecenoic acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Santora, J.E.,Palmquist, D.L. and Roehrig, K.L. Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. Journal of Nutrition 130(2), 208-215 (2000). 2.Shultz, T.D.,Chew, B.P.,Seaman, W.R., et al. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cells. Cancer Letters 63, 125-133 (1992). 3.Houseknecht, K.L.,Vanden Heuvel, J.P.,Moya-Camarena, S.Y., et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochemical and Biophysical Research Communications 244, 678-682 (1998). 4.Bassett, C.M.,Edel, A.L.,Patenaude, A.F., et al. Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice. Journal of Nutrition 140(1), 18-24 (2010). 5.Gebauer, S.K.,Chardigny, J.M.,Jakobsen, M.U., et al. Effects of ruminant trans fatty acids on cardiovascular disease and cancer: A comprehensive review of epidemiological, clinical, and mechanistic studies. Adv.Nutr. 2(4), 332-354 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 282.5 |
| 分子式 | C18H34O2 |
| CAS号 | 693-72-1 |
| 稳定性 | ≥ 1 year |
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