| 货号 | 14247-5mg |
| 描述 | Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.1 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.2 It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.2,3 However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.3 In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.4,5 |
| 别名 | 2-Amino-6-formylpteridin-4-one;Pterin-6-aldehyde; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brown, J.M.,Terada, L.S.,Grosso, M.A., et al. Xanthine oxidase produces hydrogen peroxide which contributes to reperfusion injury of ischemic, isolated, perfused rat hearts. Journal of Clinical Investigation 81, 1297-1301 (1988). 2.Spector, T. and Ferone, R. Folic acid does not inactivate xanthine oxidase. The Journal of Biological Chemisty 259(17), 10784-10786 (1984). 3.Tai, L.A. and Hwang, K.C. Regulation of xanthine oxidase activity by substrates at active sites via cooperative interactions between catalytic subunits: Implication to drug pharmacokinetics. Current Medicinal Chemistry 18(1), 69-78 (2011). 4.Yamashita, K.,Arai, T.,Fukuda, K., et al. 6-Formylpterin intracellularly generates hydrogen peroxide and restores the impaired bactericidal activity of human neutrophils. Biochemical and Biophysical Research Communications 289(1), 85-90 (2001). 5.Mori, H.,Arai, T.,Hirota, K., et al. Effects of 6-formylpterin, a xanthine oxidase inhibitor and a superoxide scavenger, on production of nitric oxide in RAW 264.7 macrophages. Biochimica et Biophysica Acta 1474(1), 93-99 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 191.1 |
| 分子式 | C7H5N5O2 |
| CAS号 | 712-30-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |