| 货号 | 14175-50mg |
| 描述 | Puerarin is a natural isoflavone isolated from plants of the genus Pueraria used in traditional Chinese herbal medicine. It is biotransformed by intestinal bacteria to give the phytoestrogens daidzein (Item No. 10005166) and equol (Item No. 13184), resulting in antithrombotic, antiallergic, and other salutary effects.1,2,3 When given intraperitoneally, puerarin evokes diverse responses by modulating serotonin receptors.4,5 This compound also suppresses lipopolysaccharide-mediated activation of NF-κB in RAW 264.6 macrophages when given at 20-40 μM.6 |
| 别名 | Kakonein;NPI 031G; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Choo, M.K.,Park, E.K.,Yoon, H.K., et al. Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. Biological and Pharmaceutical Bullentin 25(10), 1328-1332 (2002). 2.Jin, J.S.,Nishihata, T.,Kakiuchi, N., et al. Biotransformation of C-glucosylisoflavone puerarin to estrogenic (3S)-equol in co-culture of two human intestinal bacteria. Biological and Pharmaceutical Bullentin 31(8), 1621-1625 (2008). 3.Nakamura, K.,Nishihata, T.,Jin, J.S., et al. The C-glucosyl bond of puerarin was cleaved hydrolytically by a human intestinal bacterium strain PUE to yield its aglycone daidzein and an intact glucose. Chemical & Pharmaceutical Bulletin 59(1), 23-27 (2011). 4.Overstreet, D.H.,Kralic, J.E.,Morrow, A.L., et al. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacology, Biochemistry, and Behavior 75(3), 619-625 (2003). 5.Chueh, F.S.,Chang, C.P.,Chio, C.C., et al. Puerarin acts through brain serotonergic mechanisms to induce thermal effects. Journal of Pharmacological Sciences 96, 420-427 (2004). 6.Hu, W.,Yang, X.,Zhe, C., et al. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacological Reports 63, 781-789 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416.4 |
| 分子式 | C21H20O9 |
| CAS号 | 3681-99-0 |
| 稳定性 | ≥ 2 years |
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