O-7460
货号：
14009-5mg 基本售价：
7280.0 元 规格：
5 mg
产品信息
概述| 货号 | 14009-5mg |
| 描述 | In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160) by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (IC50 = 690 nM).1 It demonstrates much weaker inhibition towards human monoacylglycerol lipase and rat brain fatty acid amide hydrolase (IC50s > 10 µM) and does not bind to CB1 or CB2 cannabinoid receptors (Kis > 10 µM).1 At 0-12 mg/kg, i.p. in mice, O-7460 was reported to dose-dependently inhibit high-fat diet intake and reduce body weight.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bisogno, T.,Mahadevan, A.,Coccurello, R., et al. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects. British Journal of Pharmacology (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 478.6 |
| 分子式 | C25H48FO5P |
| CAS号 | 1572051-31-0 |
| 稳定性 | ≥ 1 year |
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