| 货号 | 13243-50mg |
| 描述 | Soluble adenylyl cyclase mediates bicarbonate-stimulated production of the ubiquitous second messenger adenosine 3’,5’-cyclic mononucleotide (cAMP).1 It is abundantly expressed in sperm, in fluid transporting tissues such as kidney cortex and medulla, and in other bicarbonate-responsive tissues and cells. KH7 is a selective inhibitor of soluble adenylyl cyclase (sAC) that has little effect on transmembrane adenylyl cyclases.2 It displays an IC50 value between 3-10 µM toward sAC.2 At 50 µM, KH7 decreases basal cAMP accumulation in sperm.2 KH7 has been used in diverse research applications including cAMP-mediated signaling events required for mammalian egg fertilization,2 sAC regulation of Na+ transport in the kidney,3 and mitochondrial-dependent apoptosis in response to various stress stimuli.4 KH7 is not active against sAC in the presence of detergents. At concentrations above 50 µM, KH7 exhibits non-specific membrane disruption effects when used on cells. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wuttke, M.S.,Buck, J., and Levin, L.R. Bicarbonate-regulated soluble adenylyl cyclase. Journal of the Pancreas 2, 154-158 (2001). 2.Hess, K.C.,Jones, B.H.,Marquez, B., et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Developmental Cell 9, 249-259 (2005). 3.Hallows, K.R.,Wang, H.,Edinger, R.S., et al. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. The Journal of Biological Chemisty 284(9), 5774-5783 (2009). 4.Kumar, S.,Kostin, S.,Flacke, J.P., et al. Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. The Journal of Biological Chemisty 284, 14760-14768 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 419.3 |
| 分子式 | C17H15BrN4O2S |
| CAS号 | 330676-02-3 |
| 稳定性 | ≥ 2 years |
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