| 货号 | 10576-5mg |
| 描述 | HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM).1,2 Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells.3,4 HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum(nowC. carbonum), a pathogen of maize.5 |
| 别名 | Toxin I (Helminthosporium carbonum); |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brosch, G.,Ransom, R.,Lechner, T., et al. Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. Plant Cell 7, 1941-1950 (1995). 2.Darkin-Rattray, S.J.,Gurnett, A.M.,Myers, R.W., et al. Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase. Proceedings of the National Academy of Sciences of the United States of America 93(23), 13143-13147 (1996). 3.Kamitani, H.,Taniura, S.,Ikawa, H., et al. Expression of 15-lipoxygenase-1 is regulated by histone acetylation in human colorectal carcinoma. Carcinogenesis 22(1), 187-191 (2001). 4.Cao, H. and Stamatoyannopoulos, G. Histone deacetylase inhibitor FK228 is a potent inducer of human fetal hemoglobin. American Journal of Hematology 81, 981-983 (2006). 5.Walton, J.D. HC-toxin. Phytochemistry 67, 1406-1413 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 436.5 |
| 分子式 | C21H32N4O6 |
| CAS号 | 83209-65-8 |
| 稳定性 | ≥ 2 years |
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