| 货号 | 1798/50 |
| 别名 | 4-[[6-[(Aminoiminomethyl)amino]-1-o |
| 供应商 | Tocris |
| 生物活性 | Serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitroandin vivo. Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 417.48 |
| 分子式 | C16H23N3O4.CH3SO3H |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 39492-01-8 |
| 参考文献 | Yukselet al (2003) Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. J.Pharmacol.Exp.Ther. 305 298. PMID: 12649382. Ohnoet al (1981) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulo-fibrinolytic system in comparison with heparin or aprotinin. Thromb.Res. 24 445. PMID: 6178174. Ohnoet al (1980) FOY: [Ethyl p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. Thromb.Res. 19 579. PMID: 6449757. Tamuraet al (1977) Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r and C1 esterase. Biochim.Biophys.Acta 484 417. PMID: 143965. |