| 货号 | 13610-10mg |
| 描述 | 13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound.1,2 It is an inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 31 and 21 nM, respectively.3 13,14-dihydro PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 (Item No. 13010) which has an IC50 value of 40 nM.4 Also, 13,14-dihydro PGE1 was shown to activate adenylate cyclase in NCB-20 hybrid cells with a Kact value of 668 nM.5 |
| 别名 | PGE0;13,14-dihydro PGE1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Änggård, E. The biological activities of three metabolites of prostaglandin E1. Acta Physiologica Scandinavica 66, 509-510 (1966). 2.Hamberg, M. and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. The Journal of Biological Chemisty 246, 6713-6721 (1971). 3.Kobzar, G.,Mardla, V.,Järving, I., et al. Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. Comparative Biochemistry and Physiology 106(2), 489-494 (1993). 4.Kobzar, G.,Mardla, V.,Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proceedings of the Estonian Academy of Sciences.Chemistry 40, 179-180 (1991). 5.Blair, I.A.,Hensby, C.N. and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships. British Journal of Pharmacology 69, 519-525 (1980). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 356.5 |
| 分子式 | C20H36O5 |
| CAS号 | 19313-28-1 |
| 稳定性 | ≥ 1 year |
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