Ac-DEVD-CHO
货号：
10017-10mg 基本售价：
7252.0 元 规格：
10 mg
产品信息
概述| 货号 | 10017-10mg |
| 描述 | Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).1,2 Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).1 Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK (Item No. 14465), are irreversible.1 Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.3 |
| 别名 | N-Ac-Asp-Glu-Val-Asp-CHO; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Garcia-Calvo, M.,Peterson, E.P.,Leiting, B., et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. The Journal of Biological Chemisty 273, 32608-32613 (1998).
2.Talanian, R.V.,Quinlan, C.,Trautz, S., et al. Substrate specificities of caspase family proteases. The Journal of Biological Chemisty 272, 9677-9682 (1997).
3.Nicholson, D.W.,Ali, A.,Thornberry, N.A., et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 502.5 |
| 分子式 | C20H30N4O11 |
| CAS号 | 184179-08-6 |
| 稳定性 | ≥ 2 years |
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