| 货号 | 1997/50 |
| 别名 | 8-Azido-5,6-dihydro-5-methyl-6-oxo- |
| 供应商 | Tocris |
| 生物活性 | High affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α1-,α2-,α3- and α5-GABAA receptors. Displays partial agonism at DI α4- and α6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 326.31 |
| 分子式 | C15H14N6O3 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol and to 10 mM in DMSO |
| CAS号 | 91917-65-6 |
| 参考文献 | Knoflachet al (1996) Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2. Mol.Pharmacol. 50 1253. PMID: 8913357. Wong and Skolnick (1992) High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors. Eur.J.Pharmacol. 225 63. PMID: 1311690. Suzdaket al (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234 1243. PMID: 3022383. |