| 货号 | 1445/25 |
| 别名 | N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetrae |
| 供应商 | Tocris |
| 生物活性 | Endogenous anandamide-like compound. Lacks affinity for CB1 receptors (Ki > 10 μM), VR1 receptors (EC50 > 10 μM) and anandamide transporters (IC50 > 50 μM) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 361.52 |
| 分子式 | C22H35NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol |
| CAS号 | 179113-91-8 |
| 参考文献 | Edingtonet al (2009) Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. J.Biol.Chem. 284 36424. PMID: 19875446. Huanget al (2001) Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. J.Biol.Chem. 276 42639. PMID: 11518719. Burnsteinet al (2000) Oxidative metabolism of anandamide. Prostaglandins Other Lipid Mediat. 61 29. PMID: 10785540. Sheskinet al (1997) Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor. J.Med.Chem. 40 659. PMID: 9057852. |