| 货号 | 1419/50 |
| 别名 | [(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2 |
| 供应商 | Tocris |
| 生物活性 | Mixed opioid receptor agonist/antagonist. Acts as a potent and full agonist at κ, a partial agonist at μandδ opioid receptors (pEC50 values are 9.45, 8.74 and 8.61 in a cAMP assay, 9.70, 8.59 and 8.49 in a [35S]GTPγS binding assay respectively). Fails to exert agonist effects at NOP receptors and antagonizes agonist-induced NOP activation. Stimulates κ-,μ- and δ-mediated analgesia and blocks NOP-induced supraspinal nociception. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 445.52 |
| 分子式 | C26H27N3O4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 119630-94-3 |
| 参考文献 | Connor and Kitchen (2006) Has the sun set on κ3-opioid receptors? Br.J.Pharmacol 147 349. PMID: 16402044. Olianaset al (2006) Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br.J.Pharmacol. 147 360. PMID: 16402046. Gistraket al (1989) Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone J.Pharmacol.Exp.Ther. 251 469. PMID: 2553921. |