| 货号 | 2853/50 |
| 别名 | α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phen |
| 供应商 | Tocris |
| 生物活性 | Muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 347.92 |
| 分子式 | C21H29NO.HCl |
| 可溶性/溶解性 | Soluble to 5 mM in water and to 10 mM in DMSO |
| CAS号 | 1235-82-1 |
| 参考文献 | Brocks (1999) Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective. J.Pharm.Pharmaceut.Sci. 239. Sudoet al (1999) Muscarinic receptor occupancy by biperiden in living human brain. Life Sci. 64 PL99. PMID: 10069534. Boldenet al (1992) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 260 576. PMID: 1346637. |