| 货号 | 0748/50 |
| 别名 | N-(N-Benzylpiperidin-4-yl)-4-iodobe |
| 供应商 | Tocris |
| 生物活性 | Combines high affinity for σ1 and moderate affinity for σ2 sites. Centrally active following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 420.29 |
| 分子式 | C19H21IN2O |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 5 mM in ethanol |
| 参考文献 | Bermack and Debonnel (2001) Modulation of serotonergic neurotransmission by short- and long-term treatments with sigma ligands Br.J.Pharmacol. 134 691. PMID: 11588125. Whittemoreet al (1997) Antagonism of N-methyl-D-aspartate receptors by σ site ligands: potency, subtype-selectivity and mechanisms of inhibition. J.Pharmacol.Exp.Ther. 282 326. PMID: 9223571. Johnet al (1994) Synthesis and characterisation of [125I]-N-(N-benzylpiperidin-4-yl)-4-iodobenzamide, a new sigma receptor radiopharmaceutical: high affinity binding to MCF-7 breast tumor cells. J.Med.Chem. 37 1737. PMID: 8021913. |